- Hughes, William (d.1600), bishop of St. Asaph, son of Hugh ap Kynric of Carnarvonshire, and Gwenllian
- Hughes, William (fl.1665-1683), horticultural writer, gardener
- Hughes, William (d.1798), writer on music, minor canon of Worcester Cathedral
- Hughes, William (1793-1825), wood-engraver, apprentice to Henry Hole in Liverpool
- Hughes, William (1803-1861), legal writer, born at Maker vicarage, Cornwall, 4th son of Sir Robert Hughes, third baronet
- Hughes, William Little (1822-1887), translator, son of William Hughes, worked in Paris as government official
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