- Hume, Alexander (1560?-1609), Scottish poet, 2nd son of Patrick Hume, 5th baron of Polwarth, founder, Marchmont family
- Hume, Alexander (d.1682), of Kennetsidehead, covenanter, portioner of Hume
- Hume, Alexander (1675-1740), 2nd Earl of Marchmont
- Hume, Alexander (1809-1851), Scottish poet, born at Kelso, son of Walter Hume
- Hume, Alexander (1811-1859), Scottish poet and musical composer, tenor in St. Paul's episcopal church, chorus-master Theatre Royal
- Hume, Alexander Hamilton (1797-1873), Australian explorer, born Paramatta, New South Wales, son of Andrew Hamilton Hume, farmer
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