I have no ready-usable python code, and doubt there is. But here is the transaltion and details, which I generated with a set of shell scripts. This explains, and should help you to get started. More details can be found by searching the web for "ECDSA signature" and "ASN1-DER structure".
48: OP_DATA_0x48: push hex 48 (decimal 72) bytes on stack
30: OP_SEQUENCE_0x30: type tag indicating SEQUENCE, begin sigscript
45: OP_LENGTH_0x45: length of R + S
02: OP_INT_0x02: type tag INTEGER indicating length
21: OP_LENGTH_0x21: this is SIG R (33 Bytes)
008377DF63977C2B:3212F11FFBF098B3
28B4F246A86D131F:AA75EFFE53CEF856
8A
02: OP_INT_0x02: type tag INTEGER indicating length
20: OP_LENGTH_0x20: this is SIG S (32 Bytes)
0C7187E5898F4DC6:05819BB6CDB7E357
EC6993CE1AD11A87:A621A7A579FE6D92
01: OP_SIGHASHALL: this terminates the ECDSA signature (ASN1-DER structure)
41: OP_DATA_0x41: length uncompressed Public Key (X9.63 form, 65 Bytes)
04A2B3AEF09705DA:98696F357DFA7860
5F6490F4115D55A8:E0A5ADA4152F77A5
0E4FAA479B0ED241:BB8699E356644DBE
8DE5058C2BBB739E:42F8928E95AD8D7A
18