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This question was asked before over at bitcointalk.org over here way back in June '11. The answer back then was a resounding no. Is this still the case?
My wallet.dat keeps growing bigger after every transaction since the client keeps generating and adding new bitcoin addresses I never intend to use. I want to stop that from happening.
It's not entirely correct to say that these addresses aren't used; they are used for change created by the transactions you make. Changing this has serious privacy implications. – Pieter Wuille – 2012-05-23T09:43:26.697
Probably most of the wallet size increase is caused by Bitcoin saving copies of all of your transactions there, not because of new keys. – theymos – 2012-05-23T13:45:06.440