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Trezor is one of the leading implementation of a hardware wallet. Its first generation won't support multisig ... because the Bitcoin network itself doesn't have strong multisig support.
What happens if a Trezor is lost or stolen? Where are the private keys it guards backed up? Is a password required to release funds stored on it?
1I will just add (since this question is from 2013) - as of 2017, Trezor supports multisig, through Copay Chrome app. – Karel Bílek – 2017-07-01T14:38:26.897